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1.
Chirurgie (Heidelb) ; 93(8): 788-801, 2022 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-34994806

RESUMO

BACKGROUND: Pancreatic cancer is the second most frequent cause of death among all forms of cancer in Germany with more than 19,000 deaths per year. The evaluation of the nationwide clinical cancer register aims to depict the reality of treatment and to improve the quality of treatment in the future by targeted analyses. METHOD: The data from the clinical cancer register of Brandenburg-Berlin for the diagnosis years 2001-2017 were analyzed with respect to the treatment of pancreatic cancer. Data from patients resident in the State of Brandenburg were evaluated with respect to epidemiological and therapeutic parameters. RESULTS: A total of 5418 patients with pancreatic cancer were documented in the register from 2001 to 2017 and 49.6% of the patients were diagnosed as having the Union for International Cancer Control (UICC) stage IV. A pancreas resection was carried out in 26.4% of the cases. In cases of cancer of the head of the pancreas the most frequent procedure was a pylorus-preserving resection with 51.8% and a pancreatectomy was carried out in 9.4%. The R0 resection rate of all pancreatic cancers in the period from 2014 to 2017 was 61.9%. After R0 resection the 5­year survival was 19%. Relevant multivariate survival factors were age, UICC stage and the residual (R) tumor classification. The case numbers per hospital had no influence on the absolute survival of patients operated on in the State of Brandenburg. CONCLUSION: The treatment reality in the State of Brandenburg for patients with pancreatic cancer corresponds to the results of international publications with respect to the key performance indicators investigated. A qualitative internationally comparable treatment of these patients is also possible in nonmetropolitan regions.


Assuntos
Pancreatectomia , Neoplasias Pancreáticas , Humanos , Pâncreas/patologia , Pancreatectomia/métodos , Neoplasias Pancreáticas/epidemiologia , Pancreaticoduodenectomia/métodos , Neoplasias Pancreáticas
2.
J Surg Case Rep ; 2021(2): rjab008, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33604020

RESUMO

Upper gastrointestinal bleeding from esophagogastric varices is a common scenario, especially in patients with portal hypertension induced by liver cirrhosis or other diseases with thrombosis of the splenic vein. However, accessory spleen as pathophysiological cause of a regional, left-sided portal hypertension and consecutive development of isolated gastric varices is rare. We report a case of recurrent gastric variceal bleeding resulting from sinistral portal hypertension associated with an accessory spleen in a patient who had traumatic splenectomy many decades before. The accessory spleen is an extremely rare cause for the development of regional, left-sided portal hypertension leading to isolated gastric varices. Minimally invasive splenectomy is a safe and efficient treatment option.

3.
Hernia ; 25(5): 1169-1181, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-32748006

RESUMO

INTRODUCTION: There are hardly any studies on the outcome of scrotal compared with medial and lateral inguinal hernias. Therefore, this present multivariable analysis of data from the Herniamed Registry compared the outcome of scrotal vs. lateral vs. medial inguinal hernias and explored the relationship between hernia localization and outcomes. METHODS: Included in the analysis were all primary elective unilateral inguinal hernias in men with scrotal, lateral or medial defect localization whose details had been entered into the Herniamed Registry by 712 participating institutions (status February 1, 2019). The relation of the hernia localization with the outcome parameters adjusted for pre-defined confounding patient- and procedure-related variables was analyzed via multivariable binary logistic models. RESULTS: Details of 98,321 patients were thus available for multivariable analysis. These related to 65,932 (67.1%) lateral, 29,697 (30.2%) medial and 2,710 (2.7%) scrotal inguinal hernias. Scrotal hernias were associated with higher patient age, higher BMI, higher ASA score, larger defect, more risk factors and more frequent use of Lichtenstein repair. On the other hand, scrotal hernias were associated less commonly with preoperative pain. Multivariable analysis revealed that scrotal hernias had a highly significantly unfavorable association with postoperative complications, complication-related reoperations and general complications. But scrotal hernias had a highly significantly favorable relation with the pain rates at 1-year follow-up. Medial hernias were the hernia type most often related with recurrence and also had an unfavorable association with the pain rates at 1-year follow-up. CONCLUSION: Scrotal inguinal hernias demonstrated a very unfavorable relation with the postoperative complication rate, the rate of complication-related reoperations and the rate of general complications. But a very favorable association with chronic pain rates was identified at 1-year follow-up. Medial inguinal hernia had an unfavorable relation with the recurrence and pain rates.


Assuntos
Dor Crônica , Hérnia Inguinal , Hérnia Inguinal/epidemiologia , Hérnia Inguinal/cirurgia , Herniorrafia/efeitos adversos , Humanos , Masculino , Recidiva , Sistema de Registros , Reoperação , Resultado do Tratamento
4.
Hernia ; 24(5): 1083-1091, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32566993

RESUMO

INTRODUCTION: The use of drains continues to be a controversial topic in surgery. In a review of that topic for incisional hernia it was not possible to find sufficient evidence of the need for a drain. Likewise, for inguinal hernia surgery the data available are insufficient. METHODS: In a multivariable analysis of data from the Herniamed Registry for 98,321 patients with primary elective unilateral inguinal hernia repair in men, the role of a drain was investigated. RESULTS: A drain was used in 24.7% (n = 24,287/98,321) of patients. These patients were on average older, had higher BMI, longer operating time and received a smaller mesh. Drains were also used more often for patients with higher ASA score, risk factors, larger defects and scrotal hernia localization as well as for Lichtenstein, TEP and suture repair. The use of drains was highly significantly associated with intra- and postoperative complications as well as with complication-related reoperations. Hence, drains are used selectively in inguinal hernia repair for patients at higher risk of perioperative complications. Despite the use of drains, the outcome in this risk group is less favorable. It remains unclear if drains prevent further complications in high-risk patients. CONCLUSION: Drains are used selectively in high-risk men with primary elective unilateral inguinal hernia repair. Drains are associated with intra- and postoperative complications rates and complication-related reoperation rate. Drains can serve as an indicator for early detection of complications.


Assuntos
Drenagem/métodos , Hérnia Inguinal/cirurgia , Herniorrafia/métodos , Humanos , Masculino
5.
Chirurg ; 84(4): 296-304, 2013 Apr.
Artigo em Alemão | MEDLINE | ID: mdl-23479273

RESUMO

The age group ≥ 80 years has become of great importance in the surgical treatment of colorectal cancer due to the demographic changes over the years. To assess patient risk, early postoperative and oncologic long-term outcome 64,740 patients with colorectal cancer were enrolled in various nationwide multicenter observational studies through two study periods (2000-2004 and 2009-2011) and analyzed according to various age groups, in particular ≥ 80 years. The percentage of octogenarians increased from 2009 to 2011, which was associated with an increased patient risk. In 70  % of patients ≥ 80 years old the operative risk was preoperatively classified as ASA stages III and IV. There was a high age-independent resection rate of colon cancer; however, the rectal cancer resection rate in octogenarians was significantly lower. In the age group ≥ 80 years there was a relatively high rate of emergency surgical interventions because of an ileus due to tumor-induced lumen obstruction leading to a hospital mortality rate in both study periods of 18.8 % and 17.9 %, respectively. In the octogenarians there were more locally advanced colon cancer lesions of stage T3/4 but less tumor lesions with distant metastases. The age-corrected tumor-free 5-year survival rate of the octogenarians with colon cancer of tumor stage UICC I-III was identical to that of younger patients.


Assuntos
Neoplasias Colorretais/cirurgia , Garantia da Qualidade dos Cuidados de Saúde/normas , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Causas de Morte , Neoplasias Colorretais/mortalidade , Neoplasias Colorretais/patologia , Progressão da Doença , Intervalo Livre de Doença , Feminino , Alemanha , Indicadores Básicos de Saúde , Mortalidade Hospitalar , Humanos , Íleus/mortalidade , Íleus/patologia , Íleus/cirurgia , Masculino , Estadiamento de Neoplasias , Dinâmica Populacional
6.
Endoscopy ; 43(5): 425-31, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21234855

RESUMO

BACKGROUND AND STUDY AIMS: This multicenter, prospective, country-wide quality-assurance study at more than 300 hospitals in Germany was designed to characterize and analyze the diagnostic accuracy of rectal endoscopic ultrasound (EUS) in the routine clinical staging of rectal carcinoma (depth of tumor infiltration). PATIENTS AND METHODS: Patients were surveyed between 1 January 2000 and 31 December 2008. Those who received neoadjuvant therapy after EUS were excluded. The correspondence between the EUS assessment of tumor depth (uT) and that determined by histology (pT) was calculated, and the influence of hospital volume upon the sensitivity, specificity, and positive and negative predictive values was investigated. RESULTS: At 384 hospitals providing care at all levels, 29 206 patients were included; of the 27 458 treated by surgical resection, EUS was performed for 12 235 (44.6 %). Of these, 7096 did not receive neoadjuvant radiochemotherapy, allowing a uT-pT comparison. The uT-pT correspondence was 64.7 % (95 % confidence interval [CI] 63.6 % - 65.8 %); the frequency of understaging was 18 % (95 %CI 17.1 % - 18.9 %) and that of overstaging was 17.3 % (95 %CI 16.4 % - 18.2 %). The kappa coefficient was greatest in the category T1 (κ = 0.591). For T3 tumors κ was 0.468. The poorest correspondence was found for T2 and T4 tumors (κ = 0.367 and 0.321, respectively). A breakdown by hospital volume showed that the uT-pT correspondence was 63.2 % (95 %CI 61.5 % - 64.9 %) for hospitals undertaking ≤ 10 EUS/year, 64.6 % (95 %CI 62.9 % - 66.2 %) for doing 11 - 30 EUS/year, and 73.1 % (95 %CI 69.4 % - 76.5 %) for those hospitals performing > 30 EUS/year. CONCLUSIONS: In clinical routine, the diagnostic accuracy of transrectal ultrasound in staging rectal carcinoma does not attain the very good results reported in the literature. Only in the hands of diagnosticians with a large case volume of rectal carcinoma patients can EUS lead to therapy-relevant decisions.


Assuntos
Carcinoma/diagnóstico por imagem , Endossonografia , Estadiamento de Neoplasias/métodos , Neoplasias Retais/diagnóstico por imagem , Carcinoma/patologia , Humanos , Valor Preditivo dos Testes , Estudos Prospectivos , Neoplasias Retais/patologia , Sensibilidade e Especificidade
7.
Eur J Surg Oncol ; 33(7): 854-61, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17933024

RESUMO

AIM: Studies analysing the outcome after resection of low rectal cancer that has not infiltrated the anal sphincter reveal poorer long-term outcomes after abdominoperineal resections (APR) in comparison with low anterior resections (LAR). Further, a relationship between the frequency of APR and LAR for low rectal cancer and hospital volume is known. Our aim was to investigate the independent impact of hospital volume and type of resection on oncological outcomes after resection of low rectal cancer. METHOD: In a prospective multi-centre observational study of 1557 patients with low rectal cancer undergoing LAR or APR, the long-term oncological outcomes were analysed for their dependence on hospital volume and type of procedure. RESULTS: Univariate analysis revealed that patients undergoing APR had a higher local recurrence rate (p = 0.022) and shorter disease-free survival (p < 0.001) than patients undergoing LAR, while hospital volume showed merely a tendency to impact the local recurrence rate (p = 0.060). With regard to disease-free survival, no dependence on hospital volume was to be found (p = 0.201). The rate of APR was significantly associated with hospital volume (p < 0.001). Multivariate analysis revealed an independent impact of hospital volume on local recurrence rate, while disease-free survival was influenced by the type of surgical procedure performed. CONCLUSION: In the surgical treatment of low rectal cancer the hospital volume has a major impact on outcome. The type of procedure does not affect the local recurrence rate but the disease free survival.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/estatística & dados numéricos , Hospitais/estatística & dados numéricos , Neoplasias Retais/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Canal Anal/cirurgia , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Intervalo Livre de Doença , Feminino , Seguimentos , Alemanha/epidemiologia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/epidemiologia , Estudos Prospectivos , Neoplasias Retais/mortalidade , Resultado do Tratamento
8.
Br J Surg ; 94(12): 1548-54, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17668888

RESUMO

BACKGROUND: : Anastomotic leakage has a major impact on morbidity and mortality in rectal cancer surgery. Its relevance to oncological outcome is controversial. This observational study investigated the influence of anastomotic leakage on oncological outcome. METHODS: : Data for 1741 patients undergoing curative resection of rectal cancer (located less than 12 cm from the anal verge) with normal healing were compared with those for 303 patients who experienced anastomotic leakage. Morbidity, mortality and long-term oncological outcomes were analysed. RESULTS: : Median follow-up was 40 months. Patients with anastomotic leakage had a higher postoperative mortality rate than those with no leakage (4.3 versus 1.2 per cent; P < 0.001). Patients with leakage necessitating surgical treatment had a higher 5-year local recurrence rate (17.5 versus 10.1 per cent; P = 0.006) and a lower 5-year disease-free survival rate (70.9 versus 75.4 per cent; P = 0.020) than those without leakage. Patients with anastomotic leakage not requiring surgical intervention did not have a worse oncological outcome. CONCLUSION: : A negative prognostic impact of anastomotic leakage on local recurrence and disease-free survival was found only for patients with leakage needing surgical revision.


Assuntos
Neoplasias Retais/cirurgia , Deiscência da Ferida Operatória/mortalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Anastomose Cirúrgica , Colostomia/mortalidade , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/etiologia , Recidiva Local de Neoplasia/mortalidade , Estudos Prospectivos , Neoplasias Retais/mortalidade , Fatores de Risco , Resultado do Tratamento
9.
J Cardiovasc Surg (Torino) ; 48(2): 181-6, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17410064

RESUMO

AIM: Analysis of risk factors for the outcome of arterial embolism of the extremities (EE). METHODS: Between 1999 and 2003, all patients (n=200) with an EE diagnosed in various departments of the hospital were recruited and analysed retrospectively (single center study). Exclusion criteria were isolated digital emboli, iatrogenic emboli and arterial thromboses. For statistical analysis was used the multivariate nominal regression. RESULTS: There were 138 (69%) leg, and 62 (31%) arm, emboli. Preoperative angiography was performed in 88 patients; a total of 119 (59.5%) cases of incomplete ischemia (leg n=69, arm n=50) were seen. The most common cause of the embolism (73%) was atrial fibrillation (AF). One hundred and seventhyt four patients (87%) were treated by primary surgery. The major amputation rate (lower limb) was 4.3%. Additional arterial emboli were seen in 14 (7%). The mortality rate was 13% (upper extremity embolism 4.8%; lower extremity embolism 16.7%; P=0.021). After discharge, 32.2% of the patients received oral anticoagulation, and 37.9% antiplatelet therapy. The statistical analysis identified postoperative cerebral/visceral thromboembolism as independent risk factor for mortality. CONCLUSIONS: The main risk factor for EE is AF. Hospital mortality is determined by comorbidity and cerebral or visceral embolism. For this reason, effective oral anticoagulation is required, but is possible in only one-third of the patients after discharge.


Assuntos
Arteriopatias Oclusivas/epidemiologia , Arteriopatias Oclusivas/terapia , Extremidades/irrigação sanguínea , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Amputação Cirúrgica/estatística & dados numéricos , Anticoagulantes/uso terapêutico , Arteriopatias Oclusivas/etiologia , Arteriopatias Oclusivas/mortalidade , Arteriopatias Oclusivas/patologia , Feminino , Alemanha/epidemiologia , Mortalidade Hospitalar , Humanos , Masculino , Prontuários Médicos , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Estudos Retrospectivos , Fatores de Risco , Índice de Gravidade de Doença
10.
Klin Padiatr ; 219(1): 30-1, 2007.
Artigo em Alemão | MEDLINE | ID: mdl-16832781

RESUMO

BACKGROUND: Benign schwannomas are uncommon soft-tissue tumors in childhood. The occurrence of an abdominal schwannoma effecting an acute postrenal failure has not been reported thus far. PATIENTS: It is to describe the case of a 14-year-old male teenager who was admitted to our department because of inappetence and oedema in his face and on both feet. Further diagnostic investigations demonstrated a 24x20x15 cm abdominal tumor, which lead to an acute postrenal failure. The resection of the intraperitoneal tumor was performed completely, the histopathological examination revealed a benign schwannoma. Subsequently, the renal function had rapidly to normalised and ten years after the operation he has had no tumor recurrence. CONCLUSIONS: Surgical excision in toto is the treatment of choice. The clinical presentation, differential diagnosis and operative strategy for benign and malignant abdominal schwannomas are discussed.


Assuntos
Neoplasias Abdominais/complicações , Hidronefrose/etiologia , Neurilemoma/complicações , Insuficiência Renal/etiologia , Obstrução Ureteral/etiologia , Neoplasias Abdominais/diagnóstico , Neoplasias Abdominais/cirurgia , Adolescente , Diagnóstico Diferencial , Seguimentos , Humanos , Hidronefrose/diagnóstico , Hidronefrose/cirurgia , Testes de Função Renal , Masculino , Neurilemoma/diagnóstico , Neurilemoma/cirurgia , Insuficiência Renal/diagnóstico , Insuficiência Renal/cirurgia , Obstrução Ureteral/diagnóstico , Obstrução Ureteral/cirurgia
12.
Surg Endosc ; 20(6): 909-14, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16738981

RESUMO

BACKGROUND: Palliative surgical interventions for the management of colonic obstruction in cases of metastasized or locally irresectable colorectal carcinoma show remarkable morbidity and mortality rates for mostly older and multimorbid patients. For manifest obstruction, placement of a self-expanding metal stent (SEMS) is considered to be a suitable minimally invasive therapeutic option. This study aimed to investigate the efficacy of stent-based treatment for malignant large bowel obstruction. METHODS: From January 1999 to June 2005, consecutive patients who had undergone placement of a SEMS for malignant colorectal obstruction were enrolled and monitored. Manifest incontinence and rectum carcinoma within 5 cm above the anocutaneous line were contraindications for SEMS implantation. For all further locations of tumor-induced stenosis, a stent was implanted using endoscopy and fluoroscopy. This case series was characterized in terms of age, carcinoma localization, complications, morbidity and mortality, and the necessity for further interventions. RESULTS: For 44 of 48 patients (92%), stents were placed successfully and obstruction was abolished. The four remaining patients experienced stent dislocation. The median of age of the patients was 77.7 years (range, 47-96 years). The distribution of malignant stenoses was as follows: rectum (n = 16, 33.3%), sigmoideal colon (n = 21, 43.8%), descending colon (n = 4, 8.3%), splenic flexure (n = 2, 4.2%), transversal colon (n = 3, 6.2%), hepatic flexure (n = 1, 2.1%), and ascending colon (n = 1, 2.1%). There was no peri-interventional morbidity or mortality. The median in situ time for the stents was 251 days (mean, 422 days), with 13 of 44 patients treated with palliative therapy showing complications (29.5%). Six patients were treated endoscopically, and three individuals underwent surgical intervention. For four patients, no further intervention was required. Overall, there was no treatment-related mortality. CONCLUSIONS: For palliative treatment of malignancy-induced colorectal obstruction, SEMS is an efficient tool associated with low morbidity and minimal mortality. From a technical point of view, all tumor locations are accessible.


Assuntos
Neoplasias Colorretais/complicações , Obstrução Intestinal/etiologia , Obstrução Intestinal/terapia , Cuidados Paliativos/métodos , Stents , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Stents/efeitos adversos , Resultado do Tratamento
13.
Eur J Surg Oncol ; 32(4): 420-5, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16520014

RESUMO

AIMS: Transrectal ultrasonography (TRUS) is the diagnostic tool of choice for local staging of rectal carcinoma. The accuracy in determining of tumour infiltration depth has been reported to reach 95% (on average, 85%). The aim of the study was to analyse the diagnostic accuracy of the TRUS in the clinical routine. PATIENTS AND METHODS: From 01/01/2000 to 12/31/2003, all patients with rectal carcinoma were enrolled in a prospective multicenter observational study. In case of complete findings of pre-operative TRUS and post-operative histological investigation of the surgical specimen on the tumour infiltration depth, overall accuracy of TRUS was determined. RESULTS: Overall, 13,610 patients with rectal carcinoma were enrolled in the study. Five thousand and fifty-six subjects (37%) underwent TRUS. In 3,501 patients, TRUS finding (uT-stage) could be compared with the result of the definitive histologic investigation (pT-stage). The accuracy of TRUS in all T-stages was 65.8%. The highest sensitivity was achieved in the T3-stage (74.9%), while in T2, T1, and T4, it was 59.6, 59.0 and 31.1%, respectively. In discriminating tumour growth limited to the rectal wall vs that through the rectal wall into the neighboring tissue, TRUS-associated accuracy was 76.5%. There were no differences between various tumour locations above the anocutaneous line. CONCLUSIONS: Diagnostic accuracy of TRUS in determining depth of tumour infiltration within or through the rectum wall in the routinuous diagnostic of rectal carcinoma does not reach the excellent published study results. A considerable improvement of the qualitative outcome in using this specific diagnostic tool appears to be recommendable to utilize its advantages such as high accuracy, efficacy, and practicability in the diagnostic process and deriving consequences for a possible neoadjuvant treatment as well as optimal planning of the surgical approach.


Assuntos
Carcinoma/diagnóstico por imagem , Carcinoma/patologia , Endossonografia , Medicina de Família e Comunidade , Estadiamento de Neoplasias/métodos , Neoplasias Retais/diagnóstico por imagem , Neoplasias Retais/patologia , Estudos de Viabilidade , Humanos , Estudos Prospectivos , Reprodutibilidade dos Testes
14.
Zentralbl Chir ; 130(5): 387-92, 2005 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-16220432

RESUMO

By means of a prospective multi centre study, 13 419 cases of surgically treated patients with rectum carcinomas were registered between 1.1.2000 and 31.12.2003 and assessed in regard to possible problems concerning indications and operative procedures. Beside a high rate of non-local resective procedures in T1-low risk carcinomas, unnecessary extirpations in cases of tumour localisation over 8 cm from the anal verge were found. Tumours of the lower two-thirds of the rectum were treated by incomplete TME in 20 % of the patients. In addition, there seems to be too low a rate of neo-adjuvant therapy procedures. Protective stomata were frequently foregone after low anterior resection. Endoscopic interventional methods were still used reluctantly in inoperable situations.


Assuntos
Garantia da Qualidade dos Cuidados de Saúde/normas , Neoplasias Retais/cirurgia , Alemanha , Mortalidade Hospitalar , Humanos , Estadiamento de Neoplasias , Cuidados Paliativos , Complicações Pós-Operatórias/mortalidade , Complicações Pós-Operatórias/patologia , Complicações Pós-Operatórias/cirurgia , Guias de Prática Clínica como Assunto , Proctoscopia/normas , Estudos Prospectivos , Neoplasias Retais/mortalidade , Neoplasias Retais/patologia , Reto/patologia , Reto/cirurgia , Reoperação , Procedimentos Desnecessários
15.
Br J Surg ; 92(9): 1137-42, 2005 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-15997447

RESUMO

BACKGROUND: Anastomotic leak is a serious complication of resection for low rectal carcinoma. METHODS: Data from a prospective multicentre study conducted between January 2000 and December 2001 were analysed to determine the early outcome after low anterior resection in patients with and without a protective stoma. The morbidity and mortality rates associated with ileostomy and colostomy closure were compared. RESULTS: Eight hundred and eighty-one (32.3 per cent) of 2729 patients received a protective stoma after low anterior resection. Overall anastomotic leak rates were similar in patients with or without a stoma (14.5 versus 14.2 per cent respectively). The incidence of leaks that required surgical intervention was significantly lower in those with a protective stoma (3.6 versus 10.1 per cent; P < 0.001), as was the mortality rate (0.9 versus 2.0 per cent; P = 0.037). Logistic regression analysis showed that provision of a protective stoma was the most powerful independent variable for avoiding an anastomotic leak that required surgical correction. Seven hundred and twenty-four of the 881 patients who received a stoma were followed up. The overall postoperative morbidity associated with stoma closure was significantly lower for colostomy than for ileostomy (15.3 versus 22.4 per cent; P = 0.031). CONCLUSION: A protective stoma reduced the rate of anastomotic leakage that required surgical intervention, and mitigated the sequelae of such leakage. Colostomy closure was associated with less morbidity than closure of an ileostomy.


Assuntos
Colostomia/efeitos adversos , Ileostomia/efeitos adversos , Complicações Pós-Operatórias/etiologia , Neoplasias Retais/cirurgia , Estomas Cirúrgicos , Idoso , Colostomia/métodos , Feminino , Humanos , Ileostomia/métodos , Masculino , Estudos Prospectivos , Deiscência da Ferida Operatória/etiologia , Deiscência da Ferida Operatória/prevenção & controle , Resultado do Tratamento
17.
Br J Anaesth ; 94(5): 596-600, 2005 May.
Artigo em Inglês | MEDLINE | ID: mdl-15734779

RESUMO

BACKGROUND: The influence of muscle relaxation on the intra-operative neuromonitoring of the recurrent laryngeal nerve during thyroid surgery is unclear. METHODS: In a prospective study involving 200 patients undergoing elective thyroid surgery, the influence of muscle relaxation on neuromonitoring of the recurrent laryngeal nerve was investigated. The patients received balanced anaesthesia with oxygen-nitrous oxide-isoflurane, and rocuronium bromide was used as the non-depolarizing neuromuscular blocking agent. The degree of relaxation was monitored continuously by accelerometry [twitch (% TW)]. Summed action potentials (SAcP) obtained from the vocalis muscle were characterized by the area under the electromyographic curve expressed in millivolt seconds. RESULTS: Evoked potentials were obtainable in all patients and at all time points. With decreasing neuromuscular blockade a significant increase in the potentials evoked at the vocalis muscle was observed. At 0% TW SAcP was 1.27 (SD 1.02) mV s. An increase in TW to 10% was accompanied by an increase in SAcP to 2.68 (2.01) mV s (P<0.01). At a TW of 25%, mean SAcPs of 5.08 mV s were recorded. CONCLUSIONS: There was a significant difference in the degree of relaxation of the adductor pollicis muscle and the vocalis muscle. The laryngeal muscles exhibited a shorter response time than the adductor pollicis and recovered more quickly. These results confirm the feasibility of intra-operative neuromonitoring of the recurrent laryngeal nerve during neuromuscular blockade.


Assuntos
Monitorização Intraoperatória/métodos , Relaxamento Muscular , Bloqueio Neuromuscular , Nervo Laríngeo Recorrente/fisiologia , Tireoidectomia/efeitos adversos , Potenciais de Ação , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anestesia por Inalação , Antropometria , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Traumatismos do Nervo Laríngeo Recorrente
18.
J Biomed Mater Res A ; 72(3): 317-25, 2005 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-15654697

RESUMO

Besides inflammation, specific immune responses are seen also after implantation of biomaterials. The aim was to investigate the humoral response to bovine collagen type I following implantation of various polyester (Dacron) prostheses into pigs. In 24 randomized pigs, the infrarenal aorta was replaced with a segment of collagen-impregnated, woven polyester prosthesis of low, medium, or high porosity. IgG antibodies were detected by immunoassay using native and denatured collagen type I as a target for blood samples taken on day 1 (implantation), 10, 17, 24, 62, and 116. As generally observed, antibodies to native and denatured collagen are of low titer and were significantly correlated with enhanced binding to the denatured form (p < 0.001). The highest overall antibody prevalence to native and denatured collagen was obtained on day 116 with 68% and on day 62 with 59%, respectively. Prostheses with high porosity induced an early immune response on day 10; those with low and medium porosity induced the highest antibody levels later after 2 months. Collagen antibodies neither correlated with serum IgG contents nor with antibodies to the prosthesis polyester matrix. Thus, humoral immune response against implant components may provide a further parameter in describing biocompatibility but also a potential marker that may facilitate monitoring of individual perigraft reaction.


Assuntos
Materiais Biocompatíveis , Prótese Vascular , Colágeno/imunologia , Imunoglobulina G/imunologia , Poliésteres , Animais , Bovinos , Feminino , Suínos , Fatores de Tempo
19.
Z Orthop Ihre Grenzgeb ; 142(6): 673-8, 2004.
Artigo em Alemão | MEDLINE | ID: mdl-15614646

RESUMO

AIM: We have carried out an observational study to determine the pre-operative risk factors for transfusion in patients undergoing implantation of a hip prosthesis. METHOD: 47 patients were recruited to the study. The following parameters were recorded: peri-operative transfusions, infusions, blood and secretion losses, re-transfusions and other operative variables. In addition, patient-specific data (age, body mass index, co-existing conditions, haemoglobin) were determined. The data were grouped by transfusions and re-transfusions and submitted to statistical analysis. RESULTS: The transfusion incidence in knee endoprosthesis implantation procedures was low at 25.5 %. Age above 74 years, ASA 3 and 4 were identified as significant risk factors for transfusion. If the significant risk groups identified in this study are left aside, a transfusion incidence of 5.6 % is found. CONCLUSION: For the implantation of an artificial hip joint, we recommend autologous blood donation only for patients with ASA 3. For other patients it is recommended that homologous banked blood (2 units of cross-matched concentrated red cells) be held in readiness.


Assuntos
Artroplastia de Quadril , Transfusão de Sangue , Osteoartrite do Quadril/cirurgia , Assistência Perioperatória , Idoso , Idoso de 80 Anos ou mais , Doadores de Sangue , Perda Sanguínea Cirúrgica/fisiopatologia , Transfusão de Sangue Autóloga , Volume Sanguíneo/fisiologia , Feminino , Hematócrito , Hemoglobinometria , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Quadril/sangue , Estudos Prospectivos , Desenho de Prótese , Retratamento , Fatores de Risco
20.
Chirurg ; 75(12): 1191-6, 2004 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-15448931

RESUMO

Based on data obtained in a prospective, multicenter trial investigating the surgical treatment of colorectal carcinomas, the aim of this study was to investigate the value and relevance of Hartmann's procedure compared with alternative surgical approaches in elective interventions and emergency situations in carcinoma of the rectum (n=10,355) and the left hemicolon (n=8,825). Only in 3.4% (n=353) of patients with rectal carcinoma was the Hartmann's procedure executed with curative intention, indicating that this approach is recommendable only in (1) rare emergency situations (1.66%, n=172), (2) selected cases with elective intervention such as high-risk patients or subjects with poor prognosis, and (3) individuals with rectal carcinoma of the lower third who require deep resection (2+3, 1.75%, n=181). However, Hartmann's procedure resulted in the lowest mortality (7.5%) of the various procedures aiming for radical resection in the case of luminal obstruction or perforation at the left hemicolon. With palliative intention, 4.3% of patients with rectal carcinoma (n=449) received primary colostomies. At the left hemicolon, palliative segmental colon resection with primary anastomosis maintaining intestinal passage showed the lowest mortality (6.1%) and perioperative morbidity (33.9%) under elective circumstances, whereas Hartmann's procedure was preferred in emergency situations.


Assuntos
Adenocarcinoma/cirurgia , Colectomia/métodos , Neoplasias Colorretais/cirurgia , Colostomia/métodos , Adenocarcinoma/diagnóstico , Adenocarcinoma/mortalidade , Adenocarcinoma/patologia , Idoso , Anastomose Cirúrgica , Colo/patologia , Neoplasias Colorretais/diagnóstico , Neoplasias Colorretais/mortalidade , Neoplasias Colorretais/patologia , Emergências , Feminino , Seguimentos , Alemanha , Mortalidade Hospitalar , Hospitais Universitários , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/mortalidade , Estudos Prospectivos , Reto/patologia , Análise de Sobrevida
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